About Us : Research Scientists

Bryan Marples, Ph.D.


Dr. Brian Marples has 25+ years’ research experience in the field of Radiation Biology, gained at the L.H. Gray Laboratory (Mount Vernon Hospital, UK) and the Paterson Institute (Christie Hospital, Manchester, UK), and most recently in the U.S. at Wayne State University and William Beaumont Hospital in Michigan. In 2016, he relocated to the Department of Radiation Oncology to become the Director of Radiobiology. His research focuses on the molecular radiation response of tumor cells and normal tissues, with an emphasis on the biological mechanisms activated by exposure to low and clinically-relevant doses of radiation, and how these events regulate cell death pathways. These studies include both cell culture investigations along with pre-clinical models harboring subcutaneous or orthotopic tumors using treatment regimens that recapitulate clinical standards of care. His research has investigated low-dose Pulsed Radiotherapy in the first-line treatment of glioblastoma, and other radiation resistant tumors such as HPV-negative head and neck squamous cell carcinomas. Complementary studies are investigating normal tissue damage after irradiation in a number of anatomical sites. These investigations include a study examining the radiation response of the kidney, to define how the individual cell populations within the kidney regulate functional activity after radiation damage. The work has shown that radiation damage reduces the levels of a specific enzyme —sphingomyelinase-like phosphodiesterase 3b (SMPDL3b) — in kidney podocyte cells, and this reduction is associated with the risk for developing radiation-induced toxicity. SMPDL3b, along with other proteins and lipids in the podocyte, regulates cellular morphology and function after radiation damage. He serves as the Biology Chair of the American Society for Therapeutic Radiology and Oncology (ASTRO) Education Committee and Science Education Program Development (SEPD) committee, and sits on the ASTRO Science Council Steering Committee. He served as the Biology Chair of American College of Radiology Radiation Oncology In-Training Examination (TXIT) committee and now sits on the American Board of Radiology (ABR) Radiation Oncology Biology Committee. He became the Senior Biology editor of the International Journal of Radiation Oncology Biology Physics (Red Journal) in October 2016.